Immune System and Behavior
Bishnoi IR; Kavaliers M; Ossenkopp K-P. Immune activation attenuates memory acquisition and consolidation of conditioned disgust (anticipatory nausea) in rats. Behavioural Brain Research, 2023, 439:114250. doi.org/10.1016/j.bbr.2022.114250
Bishnoi IR; Cloutier CL; Tyson C-D; Matic VM; Kavaliers M; Ossenkopp K-P. Infection, learning, and memory: Focus on immune activation and aversive conditioning. Neuroscience and Biobehavioral Reviews, 2022, 142:104898. doi.org/10.1016/j.neubiorev.2002.104898
Kavaliers, M; Ossenkopp K-P; Tyson, C-D; Bishnoi, IR; Choleris, E. Social factors and the neurobiology of pathogen avoidance. Biology Letters, 2022, 18:20210371. doi.org/10.1098/rsbl.2021.0371
Kavaliers M; Bishnoi IR; Ossenkopp K-P; Choleris E. Differential effects of progesterone on social recognition and the avoidance of pathogen threat by female mice. Hormones and Behavior, 2021, 127:104873. doi:10.1016/j.yhbeh.2020.104873
Kavaliers, M; Ossenkopp K-P; Choleris, E. Pathogens, odors and disgust in rodents. Neuroscience and Biobehavioral Reviews, 2020, 119:281-293. doi:10.1016/j.neubiorev.2020.09.037
Wah DTO; Kavaliers M; Bishnoi I; Ossenkopp K-P. Lipopolysaccharide (LPS) induced sickness in early adolescence alters the behavioral effects of the short-chain fatty acid, propionic acid, in late adolescence and adulthood: examining anxiety and startle reactivity. Behavioural Brain Research, 2019, 360:312-322. doi:10.1016/j.bbr.2018.12.003.
Banasikowski TJ; Cloutier CJ; Ossenkopp K-P; Kavaliers M. Repeated exposure of male mice to low doses of lipopolysaccharide: Dose and time dependent development of behavioral sensitization and tolerance in an automated light‑dark anxiety test Behavioural Brain Research, 2015, 286:241-248. doi:10.1016/j.bbr.2015.03.004
Autism Spectrum Disorder rodent model
Benitah KC; Kavaliers M; Ossenkopp K-P. Propionic acid induced behavioral effects of relevance to autism spectrum disorder evaluated in female and male rats. Pharmacology, Biochemistry and Behavior, 2023, 231:173630. doi.org/10.1016/j.pbb.2023.173630
Mepham JR; MacFabe DF; Boon F; Foley KA; Cain DP; Ossenkopp KP. Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intraventricular infusions of propionic acid: Contributions to a rodent model of ASD. Behavioural Brain Research, 2021, 403:113140. doi.org/10.1016/j.bbr.2021.113140225.
Meeking MM; MacFabe DF; Foley KA; Mepham JR; Tichenoff LJ; Boon FH; Kavaliers M; Ossenkopp K-P. Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2020, 97:109794. doi:10.1016/j.pnpbp.2019.109794
Shams S; Foley KA; Kavaliers M; MacFabe DF; Ossenkopp K-P. Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder. Developmental Psychobiology, 2019, 61(5):688-699. (invited) doi:10.1002/dev.21825
Mepham JR; Boon F; Foley KA; Cain DP; MacFabe DF; Ossenkopp KP. Impaired spatial cognition in adult rats treated with multiple intracerebroventricular (ICV) infusions of the enteric bacterial metabolite, propionic acid, and return to baseline after one week of no treatment: Contribution to a rodent model of ASD. Neurotoxicity Research, 2019, 35(4): 823-837. doi:10.1007/s12640‑019‑0002‑z
Kamen CL; Zevy DL; Bishnoi IR; Ward JM; Kavaliers M; Ossenkopp K-P. Systemic treatment with the enteric bacterial fermentation product, propionic acid, reduces acoustic startle response magnitude in rats in a dose dependent fashion: Contribution to a rodent model of ASD. Neurotoxicity Research, 2019, 35(2):353-359. doi:10.1007/s12640‑018‑9960‑9
Wah DTO; Ossenkopp K-P; Bishnoi, I; Kavaliers M. Predator odor exposure in early adolescence influences the effects of the bacterial product, propionic acid, on anxiety, sensorimotor gating, and acoustic startle response in male rats in later adolescence and adulthood. Physiology and Behavior, 2019, 199:35-46. doi:10.1016/j.physbeh.2018.11.003.
Foley KA; MacFabe DF; Kavaliers M; Ossenkopp K-P. Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: Relevance to autism spectrum disorders. Behavioural Brain Research, 2015, 278:244-256. doi:10.1016/j.bbr.2014.09.032
Conditioned Disgust
Kavaliers, M., Wah, D., Bishnoi, I. R., Ossenkopp, K.-P., & Choleris, E. (2023). Disgusted snails, Oxytocin, and the Avoidance of Infection Threat. Hormones and Behavior, 2023, 155:105424.
Kavaliers, M; Ossenkopp K-P; Tyson, C-D; Bishnoi, IR; Choleris, E. Social factors and the neurobiology of pathogen avoidance. Biology Letters, 2022, 18:20210371. doi.org/10.1098/rsbl.2021.0371
Kavaliers, M; Ossenkopp K-P; Choleris, E. Pathogen and Toxin Disgust in Rodents. In P.A. Powell and N.S. Consedine (eds.) The Handbook of Disgust Research: Modern Perspectives and Applications, Springer Nature Switzerland AG, 2021, Ch. 4, pp 53-78.
Doobay M; Cross-Mellor SK; Wah DTO; Kavaliers M; Ossenkopp K-P. Toxin-induced aversive context conditioning: Assessing active aversive behaviors conditioned to the context of an automated activity monitor. Physiology and Behavior, 2021, 240:113559.
Kavaliers M; Ossenkopp K-P; Choleris E. Social Neuroscience of Disgust. Genes, Brain and Behavior, 2019, 18(1):e12508. doi:10.1111/gbb.12508
Cloutier CJ; Zevy DL; Kavaliers M; Ossenkopp K-P. Conditioned disgust in rats (anticipatory nausea) to a context paired with the effects of the toxin LiCl: Influence of sex and the estrous cycle. Pharmacology, Biochemistry and Behavior, 2018, 173:51-57.
Cloutier CJ; Kavaliers M; Ossenkopp K-P. Lipopolysaccharide (LPS) induced sickness in adolescent female rats alters the acute-phase response and lithium chloride (LiCl)- induced impairment of conditioned place avoidance/aversion learning, following a homotypic LPS challenge in adulthood. Behavioural Brain Research, 2018, 351:121-130.
Cloutier CJ; Kavaliers M; Ossenkopp K-P. Rodent sex differences in disgust behaviors (anticipatory nausea) conditioned to a context associated with the effects of the toxin LiCl: Inhibition of conditioning following immune stimulation with lipopolysaccharide. Pharmacology, Biochemistry and Behavior, 2017, 152: 4‑12. (invited).
Boulet N; Cloutier CJ; Ossenkopp K‑P; Kavaliers M. Oxytocin, Social Factors and the Expression of Conditioned Disgust (Anticipatory Nausea) in Male Rats. Behavioural Pharmacology, 2016, 27:718-725.